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阳离子脂肪族聚碳酸酯因其独特的物理化学性质、优异的生物相容性以及结构可设计性,在生物医用领域展现出巨大的应用潜力。本文系统综述了近年来功能化阳离子脂肪族聚碳酸酯在药物递送、基因传递和抗菌材料三大领域的研究进展。详细总结了其pH值、氧化还原、ROS等智能响应性控释药物体系,高效、低毒的基因递送能力,以及广谱抗菌、协同抗菌特性,以期为高性能生物医用高分子材料的设计与应用提供参考。
Abstract:Cationic aliphatic polycarbonates have shown great application potential in the biomedical field due to their unique physicochemical properties, excellent biocompatibility and structural designability.This article systematically reviews recent research progress regarding cationic aliphatic polycarbonates across three core areas, drug delivery, gene delivery, and antimicrobial materials. Specifically, it summarizes intelligent controlled-release drug delivery systems responsive to pH value, redox, and reactive oxygen species(ROS),high-efficiency and low-toxicity gene delivery capabilities, as well as broad-spectrum and synergistic antimicrobial properties.This review aims to provide valuable references for the design and application of high-performance biomedical polymer materials.
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基本信息:
DOI:10.14173/j.cnki.hnhg.2026.09.009
中图分类号:TQ323.41
引用信息:
[1]楚延锋,王华芬,王曼,等.功能化阳离子脂肪族聚碳酸酯的应用研究进展[J].河南化工,2026,43(09):1-5.DOI:10.14173/j.cnki.hnhg.2026.09.009.
基金信息:
河南省科学院基本科研费(20260602003、20260602001);河南省科学院第二批创新创业团队(20250104); 河南省中央引导地方科技发展资金项目(Z20251831166); 河南省科技攻关项目(262102231052); 河南省理化分析测试工程技术中心平台运行(20261002001)
2026-09-08
2026-09-08